"Enhancing the Nanomaterial Bio-Interface by Addition of Mesoscale Secondary Features: Crinkling of Carbon Nanotube Films To Create Subcellular Ridges"

Xing Xie: Wenting Zhao, Hye Ryoung Lee, Chong Liu, Meng Ye, Wenjun Xie, Bianxiao Cui , Craig S. Criddle, and Yi Cui; ACS Nano, 11/12/14.

Additional Authors: Wenting Zhao, Hye Ryoung Lee, Chong Liu, Meng Ye, Wenjun Xie, Bianxiao Cui , Craig S. Criddle, and Yi Cui

Abstract:

Abstract Image

Biological cells often interact with their local environment through subcellular structures at a scale of tens to hundreds of nanometers. This study investigated whether topographic features fabricated at a similar scale would impact cellular functions by promoting the interaction between subcellular structures and nanomaterials. Crinkling of carbon nanotube films by solvent-induced swelling and shrinkage of substrate resulted in the formation of ridge features at the subcellular scale on both flat and three-dimensional substrates. Biological cells grown upon these crinkled CNT films had enhanced activity: neuronal cells grew to higher density and displayed greater cell polarization; exoelectrogenic micro-organisms transferred electrons more efficiently. The results indicate that crinkling of thin CNT films creates secondary mesoscale features that enhance attachment, growth, and electron transfer.